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The researchers behind the study used the system to model key aspects of microcephaly, a neurological condition that causes stunted brain growth and cognitive impairment. Microcephaly can be caused by a variety of genetic and environmental factors but there are currently no treatments. According to the research team, tissue masses cultured from stem cells derived from the skin of a person with microcephaly did not grow to be as large as those stem cells derived from a healthy person. The research team hypothesize that this is due to the premature differentiation of neural stem cells inside the microcephalic tissue chunks which the population of progenitor cells that fuels normal brain growth.
In the fourth week, the embryonic heart starts beating. The neural tube, which becomes the brain and spinal cord, forms. At this point, a woman has likely only been aware of her pregnancy for one week.
By the seventeenth and eighteenth week after gestation, the fetus shows a clear response to pain in multiple studies, and at least one brain pathway is mature enough to create a perception of pain. The fetus also practices breathing, crying, and breastfeeding in the womb. The fetal heart has beat over 20 million times and circulates about 55 quarts of blood per day.
Livers harvested from uPA-NOG mice transplanted by intra-splenic transplantation were disrupted by enzymatic digestion, as described [27], to preserve the viability of non-hematopoietic liver cells. Digested liver cell suspensions were held in 50ml tubes and allowed to separate, for approximately 5 minutes, into quickly-settling high-density and the remaining low-density cells. These two cell fractions were analyzed separately. 041b061a72